Synthesis of ethylenediamine tetraacetylimide by microwave

[Objective] To research the superiorities of synthesizing ethylenediamine tetraacetylimide by microwave.[Method] The optimal condition for synthesis was determined by changing the proportion of the raw materials,the power of the microwave and the time of reaction.Ethylenediamine tetraacetylimide were also synthesized by traditional way.The superiorities of microwave method were concluded by comparing results of these two methods.Finally,products were identified by comparing the infragraph of standard.[Results] The highest yield(75.6%) was obtained while the proportion of formamide and EDTA was 10.5∶1,the power of microwave was 420 W and the reaction time was 12.5 min.It was higher than the yield of traditional method(69.3%).Synthesizing ethylenediamine tetraacetylimide by using microwave just needed 3.8% of the time of original method,as well as saved 46% of formamide.Products made by this two ways and standard were checked by infragraph to ensure they were identical.[Conclusion] Synthesizing ethylenediamine tetraacetylimide by using microwave not only shorten the reaction time but also increase the yield of it and the utilization ratio of formamide compared to the traditional method.