T cell dependent liver injury in Kunming mice induced by concanavalin A

AIM To establish T cell dependent liver injury model indued by concanavalin A (ConA) in Kunming mice.METHODS According to the Tiegs's work, ConA was administered to Kunming mice via tail vein.RESULTS The specific liver injury model induced by conA was dose depedent; The histoptbolooical examinations of liver specimen showed that T lymphocytes infiltratioo in portal areas, spot necrosis and piecemeal necrosis were seen. With the inhibition of T cells activation by cyclosporine A (CSA), liver injury and infiltration of lymphocytes were not seen.CONCLSION The Successful establishment of T cell dependent liver injury in Kunming mice initiated by ConA further proved that ConA induced liver injury is not restricted to a certain mouse strain, which also provides us a more easy and suitable liver injury model for studying the mechanisms of hepatasllular destruction of viral or autoimmune hepetitis.