Objective To explore CR1 expression of peripheral blood lymphocytes of the liver cancer and digestive tract cancer patients.PBLCR1 activity and the number of its elements were detected in 58 healthy subjects and clinical diagnosis of liver cancer in 38 cases,esophageal cancer in 33 cases,34 cases of gastric cancer and 37 cases of rectal cancer.Health group PBLCR1 activity and the number of its elements was significantly higher than that of the disease;esophageal cancer group,gastric cancer and colorectal cancer than the group results of liver cancer group and the group esophageal cancer,stomach cancer group and there was no significant difference between the groups.PBLCR1 expression in digestive system cancer patients was decreased.And liver cancer patients with lung cancer had the lowest PBLCR1 expression levels.