Clinical analysis of 33 cases of gastric signet ring cell carcinoma

Objective To study the pathological characters and prognosis of 33 cases of gastric signet ring cell carcinoma.Methods The difference of clinicopathology and survival between signet ring cell carcinoma and non-signet ring cell carcinoma in 166 gastric cancer patients were analyzed restropectively.Results Thirty-three gastric signet ring cell carcinoma was observed in 166 gastric cancer samples(19.88%) and had no relationship with general pathological characters such as sex,lesion location,differentiation,depth of infiltration,lymph node metastasis,distant metastasis and clinical stage(P0.05).Gastric signet ring cell carcinoma patients were younger(age60,P=0.032) and had higher ratio of neural invasion(P=0.021) than those of non-signet ring cell carcinoma patients.The gastric signet ring cell carcinoma patients had poorer 4 years survival rate(42.4%) than that of non-signet ring cell carcinoma patients(66.2%),showing significant differences(P0.05).Conclusion The gastric signet ring cell carcinoma has a worse prognosis compared to non-signet ring cell carcinoma.