[Glomeruli manifestation of hepatitis C virus infection].

The purpose of this study was to explore the relationship between hepatitis C virus (HCV) infection and glomerulonephritis. Renal autopsy tissues taken from 21 patients with HCV infection were examined by immunohistochemical technique (S-P assay) with monoclonal anti-HCV NS3 and anti-HCV NS5. Results showed that HCAg positivity were detected in 13 out of 21 renal tissues (61.9%). 11 and 1 out of 13 were identified as membranoproliferative glomerulonephritis (MPGN) and mesangial proliferative glomerulonephritis (MsPGN) respectively, and another 1 case did not show obvious lesion. 8 out of 21 cases were negative for HCAg, in which MsPGN and membranous glomerulonephritis (MN) as well as postinfectious glomerulonephritis (PSGN) were identified in 2 and each in 1 case, respectively, except another 4 cases with no obvious lesion. The renal lesion were more common and diverse in HCV associated glomerulonephritis than hepatitis B virus (HBV) associated glomerulonephritis, the show of clinical data were similar between the two. There was HCV related glomerulonephritis and the clinical manifestation may present relevantly.