A Vortex-Assisted Microextraction Based On Deep Eutectic Solvents for Determination of Four Parabens from Cosmetic Baby Oils and Optimization by Box-Behnken Design

This study presents microextraction and determination of four parabens by vortex-assisted microextraction based on deep eutectic solvents (DESs) in cosmetic baby oils. The most suitable DES, ChCl-ethylene glycol mole ratios of DES were determined as 1:2 for use in this study. The effect of DES types has been explored at traditional one factor experiment at a time. The effect of DES volume, dilution solvent volume and vortex time on extraction recovery were examined and optimized by the Box-Behnken design. After optimum conditions were determined, vortex-assisted microextraction based on DES, 0.1-100 µg mL-1 concentration in the range of the calibration curve was plotted for all parabens. The recovery values of parabens in cosmetic baby oil samples were in the range of 82.02-101.95% and the RSDs were varied from 1.64% to 2.91%. This developed method is very suitable and effective method for the extraction of parabens from cosmetic products of similar structure.