脂质体
制造工艺
比例(比率)
微流控
可扩展性
过程(计算)
制造工程
纳米技术
工艺工程
生化工程
系统工程
计算机科学
工程类
材料科学
物理
复合材料
操作系统
数据库
量子力学
作者
Sanket M. Shah,Vivek Dhawan,René Holm,Mangal S. Nagarsenker,Yvonne Perrie
标识
DOI:10.1016/j.addr.2020.07.002
摘要
Liposomes are well recognised as effective drug delivery systems, with a range of products approved, including follow on generic products. Current manufacturing processes used to produce liposomes are generally complex multi-batch processes. Furthermore, liposome preparation processes adopted in the laboratory setting do not offer easy translation to large scale production, which may delay the development and adoption of new liposomal systems. To promote advancement and innovation in liposome manufacturing processes, this review considers the range of manufacturing processes available for liposomes, from laboratory scale and scale up, through to large-scale manufacture and evaluates their advantages and limitations. The regulatory considerations associated with the manufacture of liposomes is also discussed. New innovations that support leaner scalable technologies for liposome fabrication are outlined including self-assembling liposome systems and microfluidic production. The critical process attributes that impact on the liposome product attributes are outlined to support potential wider adoption of these innovations.
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