肠道菌群
胶质增生
发病机制
陶氏病
淀粉样变性
阿尔茨海默病
疾病
免疫学
神经退行性变
血脑屏障
生物
神经炎症
病理
炎症
转基因小鼠
医学
转基因
中枢神经系统
神经科学
生物化学
基因
作者
Min Soo Kim,Yoonhee Kim,Hyunjung Choi,Woojin Kim,Sumyung Park,Dongjoon Lee,Dong Kyu Kim,Haeng Jun Kim,Hayoung Choi,Dong Wook Hyun,Jun-Young Lee,Eun Young Choi,Dong Sup Lee,Jin‐Woo Bae,Inhee Mook‐Jung
出处
期刊:Gut
[BMJ]
日期:2019-08-30
卷期号:69 (2): 283-294
被引量:341
标识
DOI:10.1136/gutjnl-2018-317431
摘要
Cerebral amyloidosis and severe tauopathy in the brain are key pathological features of Alzheimer's disease (AD). Despite a strong influence of the intestinal microbiota on AD, the causal relationship between the gut microbiota and AD pathophysiology is still elusive.Using a recently developed AD-like pathology with amyloid and neurofibrillary tangles (ADLPAPT) transgenic mouse model of AD, which shows amyloid plaques, neurofibrillary tangles and reactive gliosis in their brains along with memory deficits, we examined the impact of the gut microbiota on AD pathogenesis.Composition of the gut microbiota in ADLPAPT mice differed from that of healthy wild-type (WT) mice. Besides, ADLPAPT mice showed a loss of epithelial barrier integrity and chronic intestinal and systemic inflammation. Both frequent transfer and transplantation of the faecal microbiota from WT mice into ADLPAPT mice ameliorated the formation of amyloid β plaques and neurofibrillary tangles, glial reactivity and cognitive impairment. Additionally, the faecal microbiota transfer reversed abnormalities in the colonic expression of genes related to intestinal macrophage activity and the circulating blood inflammatory monocytes in the ADLPAPT recipient mice.These results indicate that microbiota-mediated intestinal and systemic immune aberrations contribute to the pathogenesis of AD in ADLPAPT mice, providing new insights into the relationship between the gut (colonic gene expression, gut permeability), blood (blood immune cell population) and brain (pathology) axis and AD (memory deficits). Thus, restoring gut microbial homeostasis may have beneficial effects on AD treatment.
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