医学
敌手
控制性卵巢过度刺激
激素拮抗剂
促性腺激素释放激素拮抗剂
养生
内科学
卵巢过度刺激综合征
不育
激素
促性腺激素释放激素
怀孕
体外受精
促黄体激素
遗传学
受体
生物
作者
Zeynep Öztürk İnal,Nafiye Yılmaz,Hasan Ali İnal,Necati Hançerlioğulları,Buğra Çoşkun
出处
期刊:Journal of The Chinese Medical Association
[Ovid Technologies (Wolters Kluwer)]
日期:2018-01-01
卷期号:81 (1): 53-57
被引量:10
标识
DOI:10.1016/j.jcma.2017.01.011
摘要
Background: The aim of this study was to investigate the cost-effectiveness of antagonist administration on stimulation on days <6 and ≥6 of COH on assisted reproductive technique (ART) outcomes. Methods: In this retrospective cohort study, 412 patients who were admitted to the ART Department were evaluated. In group 1 (203 patients), antagonist administration was provided on days <6 of COH. For group 2 (209 patients), antagonist administration was provided on days ≥6 of COH. We preferred a flexible antagonist protocol in clinical practice and added an antagonist treatment regimen when dominant follicles were enlarged to 13 mm or the serum blood E2 was >300 pg/mL. Results: There were no differences between antagonist administration on days <6 and days ≥6 of COH in terms of age, BMI, duration and etiology of infertility, AFC, serum FSH, LH, peak E2 levels, the number of MII oocytes, 2PN, FR, the number of transferred embryos, and CPR per woman. However, there were statistically significant differences between the duration of stimulation, the total gonadotropin dose required, and progesterone levels on day hCG [8.26 ± 1.83 vs 9.56 ± 1.51 (p = 0.001); 2173.71 ± 860.00 vs 2749.17 ± 1079.51 (p = 0.001); 0.75 ± 0.44 vs 0.92 ± 0.59 (p = 0.002), respectively]. Conclusion: Our results have demonstrated that there was no effect of antagonist administration on days <6 and ≥6 of COH on ART outcomes. However, taking cost-effectiveness into consideration, we suggest an antagonist administration on days <6 of COH since the necessary gonadotropin dose is lower.
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