A PROSPECTIVE RANDOMISED COMPARATIVE STUDY OF EVALUATION OF EFFECT OF PROPOFOL AND DEXMEDETOMIDINE TO REDUCE SEVOFLURANE INDUCED EMERGENCE AGITATION IN YOUNG CHILDREN UNDERGOING DAY CARE SURGERY

BACKGROUND \nIn children Sevoflurane is associated with delirium upon recovery from anaesthesia, cause is not clear. It is called emergence \ndelirium or emergence agitation. This is usually seen in first thirty minutes and it is described as a disturbance in children \nawareness and attention to environment with disorientation and perceptual alterations including hypersensitivity to stimuli and \nhyperactive motor behaviour in the immediate post anaesthesia period. Propofol is effective in preventing emergence agitation \n(E.A). Dexmedetomidine is reported to reduce the frequently of EA. So we have conducted a study to evaluate, the efficacy of \npropofol in comparison with dexmedetomidine, to reduce the Emergence agitation with Sevoflurane anaesthesia in paediatric \npatients. \nMATERIALS AND METHODS \nPatient selected for this study were randomly divided in to two groups, group A, is a propofol group, group B is dexmedetomidine \ngroup. The severity of EA was evaluated by using paediatric anaesthesia emergence delirium scale (PAED) devised by Sikich \nand lerma. Incidence of emergence agitation and PAED score were noted every 5 min up to first 30 min. \nRESULTS \nRegarding Incidence of emergence agitation and PAED score, we have found that number of patient with emergence agitation \nwas more in propofol group than dexmedetomidine group at T0, T5 ,T10, T15 and T20 but not at T30. Accordingly the PAED score \nwas high in group A that is propofol group then group B at T0 ,T5 ,T10 and T15 but at T20 and T30 it was same in both the group. \nCONCLUSION \nWe have found in our study that dexmedetomidine is more effective than propofol in reducing the severity and incidence of \nemergence agitation. There is no significant difference in the duration of stay in patient in PACU but time of emergence was \nalso delayed in dexmedetomidine Group.