透视图(图形)
神经科学
发病机制
神经活性类固醇
生物
计算生物学
化学
免疫学
生物化学
计算机科学
受体
人工智能
γ-氨基丁酸受体
作者
Michelle Melgarejo da Rosa,Maria Clara Pinheiro Duarte Sampaio,Renata Virgínia Calvancanti Santos,Muhammad Sharjeel,Crysvane Araújo,Maíra Galdino da Rocha Pitta,Michelly Cristiny Pereira,Moacyr Jesus Barreto de Mello Rego
标识
DOI:10.1016/j.bcp.2021.114547
摘要
Perineural invasion (PNI) is characterized by an encounter between the cancer cells and neuronal fibers and holds an extremely poor prognosis for malignant tumors. The exact molecular mechanism behind PNI yet remains to be explored. However, it is worth-noting that an involvement of the neuroactive molecules plays a major part in this process. A complex signaling network comprising the interplay between immunological cascades and neurogenic molecules such as tumor-derived neurotrophins, neuromodulators, and growth factors constitutes an active microenvironment for PNI associated with malignancy. The present review aims at discussing the following points in relation to PNI: a) Communication between PNI and neuroplasticity mechanisms can explain the pathophysiology of poor, short and long-term outcomes in cancer patients; b) Neuroactive molecules can significantly alter the neurons and cancer cells so as to sustain PNI progression; c) Finally, careful manipulation of neurogenic pathways and/or their crosstalk with the immunological molecules implicated in PNI could provide a potential breakthrough in cancer therapeutics.
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