生物
NAD+激酶
光呼吸
生物化学
分区(防火)
苹果酸脱氢酶
C4光合作用
叶绿体
光合作用
亚细胞定位
乙醛酸循环
藻类
细胞生物学
植物
新陈代谢
细胞质
酶
基因
作者
Ousmane Dao,Franziska Kuhnert,Andreas Weber,Gilles Peltier,Yonghua Li‐Beisson
标识
DOI:10.1016/j.tplants.2021.11.007
摘要
Subcellular compartmentalization confers evolutionary advantage to eukaryotic cells but entails the need for efficient interorganelle communication. Malate functions as redox carrier and metabolic intermediate. It can be shuttled across membranes through translocators. The interconversion of malate and oxaloacetate mediated by malate dehydrogenases requires oxidation/reduction of NAD(P)H/NAD(P)+; therefore, malate trafficking serves to transport reducing equivalents and this is termed the 'malate shuttle'. Although the term 'malate shuttle' was coined more than 50 years ago, novel functions are still emerging. This review highlights recent findings on the functions of malate shuttles in photorespiration, fatty acid β-oxidation, interorganelle signaling and its putative role in CO2-concentrating mechanisms. We compare and contrast knowledge in plants and algae, thereby providing an evolutionary perspective on redox trafficking in photosynthetic eukaryotes.
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