Sensitivity to the disinhibiting effect of alcohol: The role of trait impulsivity and sex differences.

[Clarification Notice: A clarification for this article was reported online in Psychology of Addictive Behaviors on Aug 18 2022 (see record 2022-92429-001). In the original article, simultaneous linear regression analyses examined the role of sex and trait impulsivity differences in participants' unintoxicated level of behavioral impulsivity and sensitivity to alcohol-induced increases in disinhibition. High levels of trait impulsivity were associated with higher unintoxicated disinhibition; however, no sex difference in this relationship was obtained. Similarly, high attention impulsivity was associated with elevated unintoxicated disinhibition, but no sex difference in this relationship was obtained. It is likely that the inclusion of participants with ADHD in the original analyses disproportionately accounted for the sex differences initially obtained. This reanalysis suggests that behavioral disinhibition serves as a broad indicator of trait impulsivity in both men and women.] Objective: Higher trait impulsivity is associated with more impulsive responding on certain behavioral measures of disinhibition. Additionally, behavioral disinhibition is acutely elevated following alcohol consumption. The present study examined the possibility that trait impulsivity may predict individual differences in sensitivity to the disinhibiting effect of alcohol. Specifically, the present study tested the hypothesis that those with elevated trait impulsivity also experience heightened sensitivity to the disinhibiting effect of alcohol, which might further compound their tendency toward impulsive action.To test this hypothesis, data from six studies were aggregated to comprise a sample of 190 young adults. Participants completed the Barratt Impulsiveness Scale-11 (BIS-11), and behavioral disinhibition was assessed using a cued go/no-go task following consumption of 0.65 g/kg alcohol and a placebo.Alcohol increased disinhibition overall, but higher impulsivity did not predict increased sensitivity to alcohol-induced disinhibition. In men, higher levels of trait impulsivity predicted heightened disinhibition in the unintoxicated state following placebo, but this relationship was not present in women.These findings suggest significant sex differences in the relationship between trait impulsivity and disinhibition. This sex difference may explain inconsistent research findings in studies assessing links between trait and behavioral measures of impulsivity. The data also point to trait impulsivity and sensitivity to alcohol-induced disinhibition as independent constructs. (PsycInfo Database Record (c) 2022 APA, all rights reserved).