淀粉
槲皮素
生物利用度
药物输送
控制释放
化学
聚乙二醇
溶解度
自愈水凝胶
纳米颗粒
化学工程
药品
核化学
材料科学
色谱法
有机化学
纳米技术
药理学
工程类
医学
抗氧化剂
作者
M. Kokabi Moghadam,Mir Saeed Seyed Dorraji,Fatemeh Dodangeh,Hamid Reza Ashjari,Seyedeh Neda Mousavi,Mohammad Hossein Rasoulifard
标识
DOI:10.1016/j.ejps.2022.106191
摘要
In spite of quercetin advantages, its utilization as a cancer drug is confined due to its very low water solubility and bioavailability. Accordingly, we prepared a biodegradable starch-based hydrogel, using a new technique to control and improve quercetin release and bioavailability. For this purpose, the molecular structure of starch was modified by polyethylene glycol/acrylate and Fe3O4 nanoparticles were used to enhance mechanical properties of hydrogel. In order to prepare the final hydrogel drug carrier, the modified starch was directly mixed with quercetin and other additives in different ratios and cured under blue light. Synthesis confirmation and structural properties of the modified starch, silanized and pure Fe3O4 nanoparticles and final hydrogel were studied using 1H NMR, FT-IR, SEM, XRD, TGA, VSM and DLS analyses. We improved in vitro drug release to 56.62%, while the maximum release of quercetin from the starch-based hydrogel in our previous study was only 27% (Doosti et al., 2019).
科研通智能强力驱动
Strongly Powered by AbleSci AI