Insulin Lispro

The difference in amino acid composition between beef and porcine insulins and human insulin was long thought to be responsible for the immunogenicity of these animal insulins in humans. As a result, much of the effort expended to meet the world's increasing demand for insulin was devoted to the development of synthetic human insulin. However, the introduction of highly purified synthetic human insulin in the early 1980s did not entirely solve the problem of immunogenicity, and the new technology was used instead to change the amino acid structure of human insulin to make it more suitable for subcutaneous administration. This . . .