白杨素
高良姜素
沃戈宁
P-糖蛋白
莫林
化学
黄酮类
柚皮素
韧皮部
对接(动物)
药理学
流出
生物化学
类黄酮
生物
多重耐药
抗氧化剂
黄芩
山奈酚
植物
抗生素
替代医学
中医药
护理部
病理
医学
作者
Yajing Fang,Weiwei Cao,Mengmeng Xia,Siyi Pan,Xiaoyun Xu
标识
DOI:10.1021/acs.jafc.1c07694
摘要
This study aims to evaluate the interaction of flavonoid-flavonoid by inhibiting the function of P-glycoprotein (P-gp). The cellular uptake of seven substrates and eleven co-incubated inhibitors was measured in KB/MDR cells. The effect of galangin or morin on the absorption of silibinin or wogonin was carried out in the rat everted gut sacs. Docking was performed to evaluate the interactions between inhibitors and P-gp. Most substrates were greatly enhanced by at least five co-incubated inhibitors. Conversely, the increased uptake of substrates coincided with a decrease or without affecting the uptake of inhibitors, implying a competitive/non-competitive inhibition on P-gp. The enhancement effect by galangin or morin on the transport of silibinin or wogonin was verified in everted gut sacs. Docking explained the inhibition of flavonoids on P-gp by competitively binding to the ATP site. These results provide a strategy for increasing the absorption of flavonoids by co-administration.
科研通智能强力驱动
Strongly Powered by AbleSci AI