Association of Gut Microbiota and Biochemical Features in a Chinese Population With Renal Uric Acid Stone

梭杆菌门 肠道菌群 痛风 失调 尿酸 拟杆菌 高尿酸血症 人口 生物 梭杆菌 内科学 血脂异常 医学 生理学 厚壁菌 免疫学 肥胖 16S核糖体RNA 细菌 遗传学 环境卫生
作者
Cheng Cao,Bo Fan,Jin Zhu,Na Zhu,Jingyuan Cao,Dongrong Yang
出处
期刊:Frontiers in Pharmacology [Frontiers Media]
卷期号:13 被引量:2
标识
DOI:10.3389/fphar.2022.888883
摘要

Previous studies suggest that patients with nephrolithiasis exhibit dysbiosis in their gut microbiota, but those studies were conducted in calcium oxalate stone patients. We aimed to explore the association of gut microbiota and biochemical features of renal uric acid stone (UAS) patients in a Chinese population and identify the related bacteria that may affect the pathopoiesis of UAS. A case-control study of 117 patients with UAS, 123 patients with gout, and 135 healthy controls were included from January 2014 to October 2020. For each subject, data on demographics, biochemical parameters of blood and urine were analyzed. Fifteen patients with gout, 16 patients with UAS, 17 UAS patients with gout, and 17 healthy subjects were enrolled and provided fecal samples. The characteristics of gut microbiota were explored by using 16S ribosomal RNA (rRNA) gene sequencing and analyzed by using a combination of software mother and R. Hyperuricemia was the main risk factor for the development of gout and UAS. Obesity, dyslipidemia, and aciduria were unique risk factors for UAS patients. The richness, diversity, and relative abundance of dominant bacteria at the phylum and genus levels of gut microbiota in UAS patients were significantly distinct from other subjects. Abundance of Bacteroides and Fusobacterium was significantly positively correlated with the serum uric acid (UA) level of UAS patients. Fusobacteria was involved in the metabolism and degradation of certain short-chain fatty acids, amino acids, and sugars in pathopoiesis of UAS, and inhibited their synthesis pathways. Fusobacteria may be related to the pathogenesis of UAS, and this finding contributes to the personalized treatment of UAS from the perspective of maintaining micro-ecological equilibrium in gut.
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