细胞生物学
微泡
胞外囊泡
伤口愈合
小泡
间充质干细胞
生物
细胞外
再生医学
细胞内
血管生成
细胞
再生(生物学)
细胞信号
干细胞
化学
信号转导
免疫学
生物化学
小RNA
癌症研究
基因
膜
作者
Mangesh Dattu Hade,Caitlin N. Suire,James Mossell,Zucai Suo
摘要
Abstract Extracellular vesicles are membranous particles, ranging from 30 nm to 10 µm in diameter, which are released by nearly all cell types to aid in intercellular communication. These complex vesicles carry a multitude of signaling moieties from their cell of origin, such as proteins, lipids, cell surface receptors, enzymes, cytokines, metabolites, and nucleic acids. A growing body of evidence suggests that in addition to delivering cargos into target cells to facilitate intercellular communication, extracellular vesicles may also play roles in such processes as cell differentiation and proliferation, angiogenesis, stress response, and immune signaling. As these vesicles have natural biocompatibility, stability in circulation, low toxicity, and low immunogenicity, and serve as efficient carriers of molecular cargos, these nanoparticles are ideal therapeutic candidates for regenerative medicine. Exploring and identifying the homeostatic functions of extracellular vesicles may facilitate the development of new regenerative therapies. In this review, we summarize the wound healing process, difficulties in stem cell therapies for regenerative medicine, and the applications of mesenchymal stromal cell‐derived extracellular vesicles in improving and accelerating the wound healing process.
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