Post-exposure prophylaxis of rabies during pregnancy: safety and other concerns

Rabies is a 100% fatal disease caused mainly due to animal bites but can easily be prevented through timely vaccination in case of its potential exposure. Pregnancy is a special condition in which vaccination against rabies in case of its potential exposure may pose questions on its safety owing to its effect on the growing foetus. Through, this short review, we aim to explain the safety of rabies vaccines during pregnancy and its potential harms. Currently available evidences show that both vaccines and immunoglobulins against rabies are completely safe in pregnancy and adverse effects profile similar to non-pregnant state. Further, both the vaccine and immunoglobulins against rabies have no adverse effect on the growing foetus and therefore may safely be given to pregnant women in case of potential exposure.