FGF21型
医学
安普克
心力衰竭
2型糖尿病
胰岛素抵抗
氧化应激
高甘油三酯血症
内分泌学
生物信息学
糖尿病
蛋白激酶A
内科学
成纤维细胞生长因子
受体
激酶
生物
细胞生物学
甘油三酯
胆固醇
作者
Salvador Garza-González,Bianca Nieblas,María M. Solbes-Gochicoa,Julio Altamirano,Noemı́ Garcı́a
出处
期刊:Current Vascular Pharmacology
[Bentham Science]
日期:2022-03-01
卷期号:20 (3): 260-271
被引量:5
标识
DOI:10.2174/1570161120666220610151915
摘要
Western-style diet often leads to food overconsumption, which triggers the development of comorbidities, such as obesity, insulin resistance, hypercholesterolemia, hypertriglyceridemia, type 2 diabetes, and heart failure (HF). Several studies suggest that intermittent fasting (IF) protects against the development of those morbidities. This study presents evidence of the beneficial effects of IF on HF. Based on the current evidence, we discuss the potential molecular mechanisms by which IF works and where liver ketone bodies (KBs) play important roles. There is evidence that IF promotes a metabolic switch in highly metabolic organs, such as the heart, which increases the use of KBs during fasting. However, besides their role as energy substrates, KBs participate in the signaling pathways that control the expression of genes involved in oxidative stress protection and metabolism. Several molecular factors, such as adenosine monophosphate-activated protein kinase (AMPK), peroxisome proliferatoractivated receptor, fibroblast growth factor 21 (FGF21), sirtuins, and nuclear factor erythroid 2-related factor 2 (Nrf2) are involved. Furthermore, IF appears to maintain circadian rhythm, which is essential for highly metabolically active organs. Finally, we highlight the important research topics that need to be pursued to improve current knowledge and strengthen the potential of IF as a preventive and therapeutic approach to HF.
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