Producing High-Quality Single Nucleotide Polymorphism Data for Genome-Wide Association Studies

AbstractSingle-nucleotide polymorphisms (SNPs) have become the primary type of molecular genetic marker used in a diverse range of genetic and genomic studies. SNPs can be used to identify genomic regions linked to traits such as disease in genome-wide association studies, to understand population structure and diversity, or to understand mechanisms of genome evolution. One of the first steps of any SNP-based workflow, following SNP discovery, is quality control of SNP data. The protocol described here details how to perform quality control on SNP data to minimise errors in downstream analysis.Key wordsSNPsQuality controlPlinkFilteringbcftoolsvcftools