Luteinizing-Hormone-Releasing Hormone

One of the exciting advances in endocrinology has been the discovery of a family of peptidic neurohormones in the hypothalamus that stimulate or inhibit the secretion of adenohypophysial hormones. This article briefly reviews the evolution of present understanding of one of these neurohormones, the luteinizing-hormone-releasing hormone (LHRH). The clinical applications of the native hormone and its analogues are stressed since they may be used as a test for pituitary reserve for gonadotropin secretion, to induce ovulation in infertile women and as an antifertility drug.The anterior pituitary gland is under neural control but lacks a secretomotor innervation. Instead, neural control . . .