锶
雷奈酸锶
钙
化学
骨吸收
氯化锶
医学
骨质疏松症
内分泌学
内科学
有机化学
出处
期刊:Bone
[Elsevier BV]
日期:2004-07-20
卷期号:35 (3): 583-588
被引量:636
标识
DOI:10.1016/j.bone.2004.04.026
摘要
This review summarises old and more recent literature on the biological role of the bone-seeking trace metal strontium (Sr). It covers areas of chemistry, nutrition, toxicity, transport across biological membranes, homeostasis, general physiology, calcium-strontium interactions, and particularly the role of strontium in bone. The promoting action of strontium on calcium uptake into bone at moderate strontium supplementation, and the rachitogenic action of strontium at higher dietary strontium levels are emphasised. The literature is summarised of the novel antiosteoporotic drug strontium ranelate, which appears to act by a combination of reduced bone resorption and increased uptake of calcium into bone.
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