再生(生物学)
伤口愈合
疾病
细胞生物学
血管生成
炎症
转化研究
组织修复
医学
重症监护医学
生物信息学
生物
免疫学
病理
癌症研究
生物医学工程
作者
Sabine A. Eming,Paul Martin,Marjana Tomić-Canić
出处
期刊:Science Translational Medicine
[American Association for the Advancement of Science (AAAS)]
日期:2014-12-03
卷期号:6 (265)
被引量:2142
标识
DOI:10.1126/scitranslmed.3009337
摘要
The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body's natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration. In this review, we highlight emerging concepts in tissue regeneration and repair, and provide some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies.
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