药物化学
配体(生物化学)
芳基
氧化加成
亲核细胞
还原消去
作者
Mingjuan Su,Stephen L. Buchwald
标识
DOI:10.1002/anie.201201244
摘要
The incredible bulk: The first palladium-catalyzed amidation of five-membered heterocyclic bromides with multiple heteroatoms was achieved using the Pd/1 catalyst system. N-Arylated imidazoles, pyrazoles, thiazoles, pyrroles, and thiophenes were synthesized in moderate to excellent yield. Experimental results and DFT calculations point to the need for an electron-rich and sterically demanding biaryl phosphine ligand to promote these difficult reactions.
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