5-羟色胺能
致死性家族性失眠
血清素
色氨酸羟化酶
中缝
失眠症
中缝核
疾病
内科学
神经科学
内分泌学
生物
医学
心理学
精神科
朊蛋白
受体
作者
Julia Wanschitz,Stefan Klöppel,Christa Jarius,Peter Birner,T. Helga Flicker,Johannes A. Hainfellner,Pierluigi Gambetti,Marin Guentchev,Herbert Budka
标识
DOI:10.1002/1531-8249(200011)48:5<788::aid-ana13>3.0.co;2-5
摘要
Fatal familial insomnia (FFI) is a unique hereditary prion disease with characteristic disturbances of sleep. We studied the serotonergic system in 8 FFI-affected subjects by immunohistochemistry for the serotonin-synthesizing enzyme, tryptophan hydroxylase (TH). Quantification of neurons in median raphe nuclei showed no total neuronal loss in FFI but a substantial increase of TH+ neurons (approximately 62%) in FFI subjects compared with controls. Our data indicate an alteration of the serotonergic system that might represent the functional substrate of some typical symptoms of FFI.
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