丝氨酸
生物化学
糖蛋白
中性粒细胞弹性蛋白酶
肽序列
弹性蛋白酶
糖基化
天青颗粒
蛋白酶3
氨基酸
生物
单核细胞
丝氨酸蛋白酶抑制剂
趋化性
舍宾
分子生物学
丝氨酸蛋白酶
酶
蛋白酶
免疫学
炎症
髓过氧化物酶
基因
受体
作者
Jan Pohl,H. Anne Pereira,Nancy M. Martin,John K. Spitznagel
出处
期刊:FEBS Letters
[Wiley]
日期:1990-10-15
卷期号:272 (1-2): 200-204
被引量:72
标识
DOI:10.1016/0014-5793(90)80484-z
摘要
We report the amino acid sequence of CAP37, a human neutrophil granule protein with antibacterial and monocyte‐specific chemotactic activity. CAP37 is a single‐chain protein consisting of 222 amino acid residues. It has three N ‐glycosylation sites, at Asn residues 100, 114 and 145. Some species of CAP37 are glycosylated at all three sites; some at Asn‐114 alone, others at Asn‐114 and Asn‐110 or Asn‐145. CAP37 has 45% sequence identity to human neutrophil elastase, and 30–37% identity to several other granule serine proteinases. Despite these similarities, CAP37 is not a serine proteinase because the active site residues serine and histidine are replaced.
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