化学
胍
精氨酸
立体化学
肽
非对映体
环肽
肽合成
鸟氨酸
残留物(化学)
寡肽
组合化学
生物化学
氨基酸
作者
Alma Dal Pozzo,Laura Muzi,M. Moroni,Riccardo Rondanin,Roberto Castiglione,Pierfrancesco Bravo,Matteo Zanda
出处
期刊:Tetrahedron
[Elsevier]
日期:1998-05-01
卷期号:54 (22): 6019-6028
被引量:21
标识
DOI:10.1016/s0040-4020(98)00282-8
摘要
The synthesis of two peptide mimetics of RGD, α-Tfm-Arg-Gly-Asp-Phe-NH2 9 and α-Tfm-Arg-Gly-Asp-NH-(CH2)2-C6H5 13, is described. The precursor of α-Tfm-ornithine was obtained in two synthetic steps from 2-N-Cbz-2-Tfm-hexanediacid-1-alkyl ester and introduced into the peptide chain by α-carboxy-group activation via oxazolone. The introduction of the guanidine residue led to the final peptides as mixtures of the two diastereomers. Configurationally pure peptides were obtained in good yields by RP-HPLC.
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