Novel synthesis of (−)-Secologanin aglucon-O-silyl ether from (+)-genipin via oxidative fragmentation of γ-hydroxyalkylstannane

Abstract The synthesis of (−)-Secologanin aglucone-O-silyl ether was achieved via the oxidative fragmentation of γ-hydroxyalkylstannane which was obtained by 1,4-addition of tributyltin to cisoid enone derived from (+)- genipin.