明胶
肉芽组织
生物相容性
壳聚糖
生物医学工程
伤口愈合
化学
肿胀 的
自愈水凝胶
材料科学
高分子化学
外科
医学
生物化学
有机化学
作者
Xin Huang,Yaqing Zhang,Xiangmei Zhang,Ling Xu,Xin Chen,Shicheng Wei
标识
DOI:10.1016/j.msec.2013.07.044
摘要
A series of carboxymethyl chitosan (CM-chitosan) and gelatin hydrogels were prepared by radiation crosslinking. A pre-clinical study was performed by implantation model and full-thickness cutaneous wound model in Sprague-Dawley rats to preliminarily evaluate the biocompatibility, biodegradability and effects on healing. In the implantation test, as a component of the hydrogels, CM-chitosan showed a positive effect on promoting cell proliferation and neovascularization, while gelatin was efficient to stabilize the structure and prolong the degradation time. To evaluate the function on wound healing, the hydrogels were applied to the relatively large full-thickness cutaneous wounds (Φ3.0 cm). Compared with the control groups, the hydrogel group showed significantly higher percentage of wound closure on days 9, 12 and 15 postoperatively, which was consistent with the significantly thicker granulation tissue on days 3 and 6. All results apparently revealed that the radiation crosslinked CM-chitosan/Gelatin hydrogels could induce granulation tissue formation and accelerate the wound healing.
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