真核转录
抄写(语言学)
转录因子
计算生物学
生物
一般转录因子
增强子
遗传学
转录协同调节子
DNA
塔夫2
细胞生物学
发起人
基因
基因表达
哲学
语言学
标识
DOI:10.1016/s0959-440x(02)00296-8
摘要
Recently determined high-resolution structures of eukaryotic transcription factors have illuminated the enzymatic mechanism underlying transcription. Progress has been made in characterising protein-protein interactions between negative cofactors and general transcription factors, and between transrepression domains and corepressors. Structures of sequence-specific transcription factors have revealed further versatility in the mode of interaction with DNA and several have provided new insights into the molecular basis of human disease.
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