化学
氨
水解
比例(比率)
过程(计算)
组合化学
序列(生物学)
生化工程
工艺工程
有机化学
计算机科学
生物化学
工程类
量子力学
操作系统
物理
作者
Zhao‐Xue Yu,Fei Sha,Peng Wang
出处
期刊:Letters in Organic Chemistry
[Bentham Science]
日期:2016-09-21
卷期号:13 (6): 450-452
标识
DOI:10.2174/1570178613666160728154935
摘要
An efficient process for the large-scale synthesis of 4-methylnicotinic acid is developed. The synthetic route utilized 2,6-dichloro-4-methylnicotinonitrile as the starting material, which was commercially available. The key step in the sequence was the reductive dechlorination in the presence of zinc and ammonia to provide an intermediate which was hydrolyzed to the described acid. The reaction parameters optimization and improvement of purification are also presented. This approach, suitable for batch processing, is of interest basically to research laboratories and also to suppliers in the research and fine chemicals market. Keywords: 4-Methylnicotinic acid, dechlorination, synthesis.
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