医学
内科学
荟萃分析
危险系数
优势比
置信区间
肝细胞癌
科克伦图书馆
胃肠病学
单变量分析
细胞角蛋白
多元分析
肿瘤科
存活率
免疫组织化学
作者
Dawei Sun,Yingyi Zhang,Xu Sun,Yuguo Chen,Wei Qiu,Min Ji,Guoyue Lv
标识
DOI:10.1016/j.cca.2015.06.027
摘要
Although many studies have investigated the relationship between cytokeratin 19 (CK-19) and hepatocellular carcinoma (HCC), the prognostic value of CK-19 in HCC remains inconclusive. Eligible studies were sought in PubMed, Embase, Web of Science, Cochrane Library and Wanfang databases. Pooled hazard ratios (HRs) and odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated. 17 studies with 2943 patients were included in this meta-analysis. Meta-analysis results showed that CK-19 over-expression was significantly associated with overall survival (OS) (HR = 1.60, 95% CI: 1.32–1.93, univariate analysis; HR = 2.25, 95% CI: 1.79–2.83, multivariate analysis) and disease-free survival (DFS) (HR = 1.68, 95% CI: 1.35–2.10, univariate analysis; HR = 1.97, 95% CI: 1.54–2.53, multivariate analysis). Meanwhile, CK-19 over-expression was also correlated with decreased 1-year OS rate (OR = 0.32, 95% CI: 0.21–0.50), 5-year OS rate (OR = 0.44, 95% CI: 0.14–0.87) and 1-year DFS rate (OR = 0.51, 95% CI: 0.34–0.76), but not with 5-year DFS rate (OR = 0.62, 95% CI: 0.35–1.10). These results suggested that CK-19 over-expression was significantly associated with poor survival rate and early tumor recurrence rate in HCC patients. CK-19 can serve as an indicator of poor prognosis as well as a novel target for treatment in HCC.
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