泛素连接酶
乳腺癌
转移
内德4
癌症研究
钙粘蛋白
转移性乳腺癌
癌症
上皮-间质转换
泛素
生物
医学
内科学
细胞
基因
生物化学
作者
Meng Luo,Jinfan Li,Qi Yang,Shengyuan Xu,Kun Zhang,Jing Chen,Suzhan Zhang,Shu Zheng,Jiaojiao Zhou
出处
期刊:Cancer Letters
[Elsevier]
日期:2022-12-01
卷期号:550: 215926-215926
被引量:7
标识
DOI:10.1016/j.canlet.2022.215926
摘要
The molecular mechanisms driving metastatic progression in breast cancer patients remain poorly understood. Here, we identified N4BP3 as a new regulator in promoting breast cancer metastasis. N4BP3 is enriched in breast tumor tissue and negatively correlates with clinical outcomes in breast cancer patients. The results show that N4BP3 plays a crucial role in regulating breast cancer cell invasion in vitro, and N4BP3 depletion suppresses metastases formation in vivo. N4BP3 alters the expression of epithelial-mesenchymal transition markers and specifically targets E-cadherin in breast cancer cells. Intriguingly, we identified a novel E3 ligase NEDD4 for E-cadherin, and further revealed that N4BP3 promotes breast cancer metastasis via NEDD4-mediated E-cadherin ubiquitination and degradation. Together, this study uncovers an unprecedented role for N4BP3 in breast cancer metastasis and elucidates the underlying molecular mechanisms.
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