Efficient, Concise, and Chemoselective Synthesis of 1H‐Benzo[f]indole‐4,9‐dione with 4‐Hydroxycoumarin Substituent via a One‐Pot Three‐Component Reaction

Abstract Extensive studies on the biological activities of several quinone‐fused heterocycles have confirmed their outstanding antitumor activity. Therefore, a new family of 1 H ‐benzo[ f ]indole‐4,9‐dione derivatives with the 4‐hydroxycoumarin substitution was prepared by a high‐yield, one‐pot, concise three‐component reaction between arylglyoxals, 4‐hydroxycoumarin, and 2‐aminonaphthalene‐1,4‐dione derivatives under reflux in EtOH. This efficient protocol showed chemoselectivity in addition to facile operation procedure and easy purification.