医学
糖尿病
体内
纳米颗粒
药理学
内分泌学
纳米技术
生物
生物技术
材料科学
作者
Z. Wang,Jing Ma,Ming-Chu Xi,Dong Yin,Liangfu Jiang,Jun Qi
出处
期刊:Journal of Burn Care & Research
[Oxford University Press]
日期:2024-01-17
摘要
Abstract Diabetic wound is one of the serious complications of diabetes, and the wound is persistent and easily recurring, which seriously endangers the health and life of patients. How to effectively promote the healing of diabetic wounds has been a hot spot and difficult area of clinical research. Some previous studies have shown that dihydromyricetin has the effects of regulating blood glucose, controlling the severity, and inhibiting scarring. In the present study, we used polylactic-co-glycolic acid nanoparticles as a carrier to load dihydromyricetin to make drug-loaded nanoparticles and applied them dropwise (200 µL) to diabetic mice wounds by topical application to observe the healing and scar formation of diabetic wounds. We found that the healing rate of the diabetic mice was faster and the scar formation was less obvious. In addition, the elevated blood glucose level and weight loss of the mice in the treatment group were also reduced. Therefore, nanoparticle-mediated dihydromyricetin may be an effective treatment for diabetic wounds.
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