医学
右美托咪定
心肌病
败血症
内科学
β氧化
内分泌学
心功能曲线
糖酵解
感染性休克
心脏病学
心力衰竭
新陈代谢
麻醉
镇静
作者
Yaqian Xu,Xue Zhang,Xiangxu Tang,Chanjuan Zhang,Jason Cahoon,Yingwei Wang,Hongmei Li,Xiuxiu Lv,Yiyang Wang,Zhi Wang,Huadong Wang,Duomeng Yang
标识
DOI:10.1016/j.biopha.2023.115993
摘要
Cardiomyopathy is a common complication and significantly increases the risk of death in septic patients. Our previous study demonstrated that post-treatment with dexmedetomidine (DEX) aggravates septic cardiomyopathy. However, the mechanisms for the side effect of DEX post-treatment on septic cardiomyopathy are not well-defined. Here we employed a cecal ligation and puncture (CLP) model and α2A-adrenoceptor deficient (Adra2a-/-) mice to observe the effects of DEX post-treatment on myocardial metabolic disturbances in sepsis. CLP mice displayed significant cardiac dysfunction, altered mitochondrial dynamics, reduced cardiac lipid and glucose uptake, impaired fatty acid and glucose oxidation, enhanced glycolysis and decreased ATP production in the myocardium, almost all of which were dramatically enhanced by DEX post-treatment in septic mice. In Adra2a-/- mice, DEX post-treatment did not affect cardiac dysfunction and metabolic disruptions in CLP-induced sepsis. Additionally, Adra2a-/- mice exhibited impaired cardiac function, damaged myocardial mitochondrial structures, and disturbed fatty acid metabolism and glucose oxidation. In sum, DEX post-treatment exacerbates metabolic disturbances in septic cardiomyopathy in a α2A-adrenoceptor dependent manner.
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