微球
Boosting(机器学习)
材料科学
粘附
纳米技术
化学工程
复合材料
计算机科学
工程类
人工智能
作者
Chenmin Yao,Shengjie Liang,Min Yu,Hongling Wu,Mohammed H. Ahmed,Y. Liu,Jianming Yu,Yan Zhao,Bart Van der Bruggen,Cui Huang,Bart Van Meerbeek
出处
期刊:Small
[Wiley]
日期:2024-02-16
标识
DOI:10.1002/smll.202310251
摘要
Abstract Dental adhesives are widely used in daily practice for minimally invasive restorative dentistry but suffer from bond degradation and biofilm attack. Bio‐inspired by marine mussels having excellent surface‐adhesion capability and high chemical affinity of polydopamine (PDA) to metal ions, herein, experimental zinc (Zn)‐containing polydopamine‐based adhesive formulation, further being referred to as “Zn–PDA@SiO 2 ”‐incorporated adhesive is proposed as a novel dental adhesive. Different Zn contents (5 and 10 m m ) of Zn–PDA@SiO 2 are prepared. Considering the synergistic effect of Zn and PDA, Zn–PDA@SiO 2 not only presents excellent antibacterial potential and notably inhibits enzymatic activity (soluble and matrix‐bound proteases), but also exhibits superior biocompatibility and biosafety in vitro/vivo. The long‐term bond stability is substantially improved by adding 5 wt% 5 m m Zn–PDA@SiO 2 to the primer. The aged bond strength of the experimentally formulated dental adhesives applied in self‐etch (SE) bonding mode is 1.9 times higher than that of the SE gold‐standard adhesive. Molecular dynamics calculations indicate the stable formation of covalent bonds, Zn‐assisted coordinative bonds, and hydrogen bonds between PDA and collagen. Overall, this bioinspired dental adhesive provides an avenue technology for innovative biomedical applications and has already revealed promising perspectives for dental restorative dentistry.
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