河马信号通路
免疫系统
细胞生物学
生物
信号转导
计算生物学
化学
癌症研究
免疫学
作者
Jingjing Zhou,Lanfang Li,Bingcheng Wu,Feng Zhu,Li Y,Zuoyun Wang
标识
DOI:10.1016/j.canlet.2024.216736
摘要
The Hippo signaling pathway is first found in Drosophila and is highly conserved in evolution. Previous studies on this pathway in mammals have revealed its key role in cell proliferation and differentiation, organ size control, and carcinogenesis. Apart from these, recent findings indicate that mammalian Ste20-like kinases 1 and 2 (MST1/2) have significant effects on immune regulation. In this review, we summarize the updated understanding of how MST1/2 affect the regulation of the immune system and the specific mechanism. The effect of MST1/2 on immune cells and its role in the tumor immune microenvironment can alter the body's response to tumor cells. The relationship between MST1/2 and the immune system suggests new directions in the manipulation of immune responses for clinical immunotherapy, especially for tumor treatment.
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