Phosphoinositide‐3 kinase activity in severe eosinophilic asthma with recurrent airway infections and neutrophilic exacerbations

Clinical & Experimental AllergyEarly View RESEARCH LETTER Phosphoinositide-3 kinase activity in severe eosinophilic asthma with recurrent airway infections and neutrophilic exacerbations Anurag Bhalla, Anurag Bhalla Division of Respirology, Western University, London, Ontario, CanadaSearch for more papers by this authorKatherine Radford, Katherine Radford Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorKiho Son, Kiho Son Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorKayla Zhang, Kayla Zhang Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorChynna Huang, Chynna Huang Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorMelanie Kjarsgaard, Melanie Kjarsgaard Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorNicola LaVigne, Nicola LaVigne Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorZachary Brautigam, Zachary Brautigam Population Health Research Institute, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorSarah Svenningsen, Sarah Svenningsen Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorGuillaume Paré, Guillaume Paré Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorManali Mukherjee, Manali Mukherjee orcid.org/0000-0002-7924-7211 Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorParameswaran Nair, Corresponding Author Parameswaran Nair [email protected] orcid.org/0000-0002-1041-9492 Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, Canada Correspondence Parameswaran Nair, Firestone Institute for Respiratory Health, St Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, ON L8N 4A6, Canada. Email: [email protected]Search for more papers by this author Anurag Bhalla, Anurag Bhalla Division of Respirology, Western University, London, Ontario, CanadaSearch for more papers by this authorKatherine Radford, Katherine Radford Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorKiho Son, Kiho Son Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorKayla Zhang, Kayla Zhang Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorChynna Huang, Chynna Huang Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorMelanie Kjarsgaard, Melanie Kjarsgaard Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorNicola LaVigne, Nicola LaVigne Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorZachary Brautigam, Zachary Brautigam Population Health Research Institute, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorSarah Svenningsen, Sarah Svenningsen Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorGuillaume Paré, Guillaume Paré Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorManali Mukherjee, Manali Mukherjee orcid.org/0000-0002-7924-7211 Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorParameswaran Nair, Corresponding Author Parameswaran Nair [email protected] orcid.org/0000-0002-1041-9492 Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, Canada Correspondence Parameswaran Nair, Firestone Institute for Respiratory Health, St Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, ON L8N 4A6, Canada. Email: [email protected]Search for more papers by this author First published: 11 March 2024 https://doi.org/10.1111/cea.14471Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Open Research DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description cea14471-sup-0001-AppendixS1.zipZip archive, 1.2 MB Appendix S1 Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. REFERENCES 1Chu DK, Al-Garawi A, Llop-Guevara A, et al. Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma. Allergy Asthma Clin Immunol. 2015; 11(1): 14. 10.1186/s13223-015-0081-1 PubMedWeb of Science®Google Scholar 2Kim JS, Jeong JS, Kwon SH, Kim SR, Lee YC. Roles of PI3K pan-inhibitors and PI3K-δ inhibitors in allergic lung inflammation: a systematic review and meta-analysis. Sci Rep. 2020; 10(1): 7608. 10.1038/s41598-020-64594-0 CASPubMedWeb of Science®Google Scholar 3Kim RY, Horvat JC, Pinkerton JW, et al. 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