星形胶质增生
肌萎缩侧索硬化
神经保护
胶质增生
神经科学
星形胶质细胞
神经营养因子
神经退行性变
疾病
医学
趋化因子
多发性硬化
中枢神经系统
生物
免疫学
炎症
病理
内科学
受体
作者
Amirhossein Sahebkar,Fatemeh Forouzanfar,Ali Mohammad Pourbagher‐Shahri,Farzaneh Vafaee,Thozhukat Sathyapalan
标识
DOI:10.2174/0929867330666230504121523
摘要
Astrocytes are a multifunctional subset of glial cells that are important in maintaining the health and function of the central nervous system (CNS). Reactive astrocytes may release inflammatory mediators, chemokines, and cytokines, as well as neurotrophic factors. There may be neuroprotective (e.g., cytokines, like IL-6 and TGF-b) and neurotoxic effects (e.g., IL-1β and TNF-a) associated with these molecules. In response to CNS pathologies, astrocytes go to a state called astrogliosis which produces diverse and heterogenic functions specific to the pathology. Astrogliosis has been linked to the progression of many neurodegenerative disorders. Phytochemicals are a large group of compounds derived from natural herbs with health benefits. This review will summarize how several phytochemicals affect neurodegenerative diseases (e.g., Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, and Parkinson's disease) in basic medical and clinical studies and how they might affect astrogliosis in the process.
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