医学
四分位数
狭窄
优势比
内科学
纤维蛋白原
冲程(发动机)
无症状的
逻辑回归
置信区间
心脏病学
单变量分析
多元分析
机械工程
工程类
作者
X. Wang,Yuesong Pan,Runhua Zhang,Mengxing Wang,Haiqiang Qin,Xia Meng,Zixiao Li,Hao Li,Yilong Wang,Wenjuan Wang,Yongjun Wang,Gaifen Liu
标识
DOI:10.1177/00033197231190514
摘要
The association between the fibrinogen-to-albumin ratio (FAR) and intracranial arterial stenosis (ICAS) in patients with acute ischemic stroke (AIS) has not yet been reported. In this large-scale investigation, 7894 AIS patients with ICAS-evaluation imaging data from the Third China National Stroke Registry were included. ICAS was defined as >50% stenosis of the intracranial arteries. We dichotomized the degree of ICAS into stenosis and occlusion. The number of ICAS lesions was the total number of intracranial stenotic arteries. Fibrinogen and albumin levels were assessed in the central laboratory of Beijing Tiantan Hospital. Univariate and multivariate analyses with logistic regression were used to determine the association between the FAR quartiles and ICAS. A total of 3900 (49.66%) patients had ICAS. Compared with those of the lowest FAR quartile, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of the highest FAR quartile were 1.26 (1.10–1.44), 1.15 (.99–1.33), and 1.19 (1.01–1.39) for ICAS, symptomatic ICAS, and asymptomatic ICAS, respectively. An elevated FAR was also associated with occlusion (adjusted OR: 1.28, 95% CI: 1.10–1.49) and lesion number ≥2 (adjusted OR: 1.25, 95% CI: 1.07–1.45).
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