Efficient Cross‐Dehydrogenative Coupling (CDC) Enabled by Cu‐PMo12 towards the Synthesis of Pyrimidinyl Carbamates at Room Temperature

Abstract A novel and efficient approach has been developed for the direct synthesis of pyrimidinyl dimethylcarbamate using Cu‐PMo 12 complex. Basically, Cu‐PMA catalyst successfully enabled the cross‐dehydrogenative coupling (CDC) reaction between N‐benzoyl cytosine and formamides in the presence of tert ‐butyl hydroperoxide and triethyl amine. Herein, Cu(I/II) catalytic system facilitated the oxidative coupling of the carbamide function, generating a new C−O bond and has been identified as more efficient compared to other commercially available Cu (I) or Cu (II) salts. Furthermore, the characterization of the catalyst was performed by XPS, SEM and EDX analysis. The present method also demonstrates a simple procedure with least catalyst loading, a wide variety of substrates with excellent functional group compatibility, high yields, ambient conditions, and operational simplicity.