催化作用
赫克反应
化学
链条(单位)
过程(计算)
组合化学
有机化学
钯
计算机科学
物理
天文
操作系统
作者
Peter H. M. Budzelaar,Manfred Bochmann,Martina Landrini,Luca Rocchigiani
标识
DOI:10.1002/anie.202317774
摘要
Two recent high-profile publications reported the formation of Heck-type arylated alkenes catalysed by MeDalPhosAuCl/AgOTf (J. Am. Chem. Soc. 2023, 145, 8810) and their cyclisation to tetralines (Angew. Chem. Int. Ed. 2023, e202312786). It was claimed that these were the first demonstrations in gold catalysis of alkene insertion into Au-aryl bonds, β-H elimination and chain-walking by Au-H dications. We show here that in fact this chemistry is a two-stage process. Only the first step, the production of an alkyl triflate ester as the primary organic product by the well-known alkene heteroarylation sequence, involves gold. The subsequent formation of Heck-type olefins and their cyclisation to tetralines represent classical H
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