亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

The Cys/N-degron pathway in the ubiquitin–proteasome system and autophagy

德隆 蛋白酶体 生物 蛋白质水解 泛素 自噬 细胞生物学 半胱氨酸 生物化学 溶酶体 泛素蛋白连接酶类 蛋白质降解 泛素连接酶 基因 细胞凋亡
作者
Ah Jung Heo,Chang Hoon Ji,Yong Tae Kwon
出处
期刊:Trends in Cell Biology [Elsevier BV]
卷期号:33 (3): 247-259 被引量:26
标识
DOI:10.1016/j.tcb.2022.07.005
摘要

All 20 amino acids can serve as N-degrons, directly or through post-translational modifications, when exposed at the protein N termini, providing a means for degrading all cellular proteins. Nt-Arg is a common element in the N-degrons generated from post-translational modifications of Cys as well as Asn, Gln, Asp, and Glu at the N termini. The resulting N-degrons are differentially recognized by a set of N-recognins for proteolysis via either the UPS or autophagy. The N-degron Cys mediates O2-dependent proteolysis through its oxidation and arginylation, which generates two structurally distinct N-degrons, leading to proteolysis by either the UPS or autophagy. Mammals and plants employ this unique chemical property of Nt-Cys to sense and react to acute and chronic hypoxia as well as oxidative stress by adjusting cellular concentrations of proteins carrying the N-degron Cys. The N-degron pathway is a degradative system in which the N-terminal residues of proteins modulate the half-lives of proteins and other cellular materials. The majority of amino acids in the genetic code have the potential to induce cis or trans degradation in diverse processes, which requires selective recognition between N-degrons and cognate N-recognins. Of particular interest is the Cys/N-degron branch, in which the N-terminal cysteine (Nt-Cys) induces proteolysis via either the ubiquitin (Ub)–proteasome system (UPS) or the autophagy–lysosome pathway (ALP), depending on physiological conditions. Recent studies provided new insights into the central role of Nt-Cys in sensing the fluctuating levels of oxygen and reactive oxygen species (ROS). Here, we discuss the components, regulations, and functions of the Cys/N-degron pathway. The N-degron pathway is a degradative system in which the N-terminal residues of proteins modulate the half-lives of proteins and other cellular materials. The majority of amino acids in the genetic code have the potential to induce cis or trans degradation in diverse processes, which requires selective recognition between N-degrons and cognate N-recognins. Of particular interest is the Cys/N-degron branch, in which the N-terminal cysteine (Nt-Cys) induces proteolysis via either the ubiquitin (Ub)–proteasome system (UPS) or the autophagy–lysosome pathway (ALP), depending on physiological conditions. Recent studies provided new insights into the central role of Nt-Cys in sensing the fluctuating levels of oxygen and reactive oxygen species (ROS). Here, we discuss the components, regulations, and functions of the Cys/N-degron pathway. degradation of a protein driven by the destabilizing activity of a built-in degron. part of the N-degron pathway in which Nt-Cys acts as a degradation determinant and generates the N-degron Arg through oxidation and arginylation. a protein that recognizes a specific substrate and accelerates the transfer of Ub from an E2 enzyme to the substrate. a class of degrons in which the N-terminal destabilizing residue is the major degradation determinant in substrate recognition. a recognition component of the N-degron pathway that recognizes N-degrons for degradation. an N-terminal degradation determinant whose modification can generate an N-degron. codegradation of an otherwise stable protein that occurs when another protein undergoes cis degradation. a ~70-residue zinc-finger motif that acts as a substrate recognition domain for type-1 substrates of the N-degron pathway.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
10秒前
bc举报微不足道求助涉嫌违规
42秒前
1分钟前
学术混子完成签到,获得积分10
1分钟前
bc举报Gummybear求助涉嫌违规
1分钟前
2分钟前
Owen应助小人物采纳,获得20
2分钟前
国色不染尘完成签到,获得积分10
2分钟前
2分钟前
饼干发布了新的文献求助10
2分钟前
饼干完成签到,获得积分20
2分钟前
2分钟前
传奇3应助LYL采纳,获得10
2分钟前
3分钟前
3分钟前
3分钟前
彭于晏应助11采纳,获得10
3分钟前
3分钟前
11发布了新的文献求助10
3分钟前
bkagyin应助科研通管家采纳,获得10
4分钟前
老石完成签到 ,获得积分10
4分钟前
4分钟前
称心如意完成签到 ,获得积分10
4分钟前
4分钟前
4分钟前
4分钟前
LYL发布了新的文献求助10
4分钟前
桐桐应助11采纳,获得10
5分钟前
5分钟前
123完成签到,获得积分10
5分钟前
11发布了新的文献求助10
5分钟前
Denmark完成签到 ,获得积分10
5分钟前
6分钟前
6分钟前
6分钟前
Roentgenstrahlen完成签到,获得积分10
6分钟前
6分钟前
6分钟前
6分钟前
7分钟前
高分求助中
Les Mantodea de Guyane Insecta, Polyneoptera 2500
One Man Talking: Selected Essays of Shao Xunmei, 1929–1939 (PDF!) 1000
Technologies supporting mass customization of apparel: A pilot project 450
A Field Guide to the Amphibians and Reptiles of Madagascar - Frank Glaw and Miguel Vences - 3rd Edition 400
China Gadabouts: New Frontiers of Humanitarian Nursing, 1941–51 400
The Healthy Socialist Life in Maoist China, 1949–1980 400
Walking a Tightrope: Memories of Wu Jieping, Personal Physician to China's Leaders 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3788267
求助须知:如何正确求助?哪些是违规求助? 3333714
关于积分的说明 10263197
捐赠科研通 3049588
什么是DOI,文献DOI怎么找? 1673634
邀请新用户注册赠送积分活动 802090
科研通“疑难数据库(出版商)”最低求助积分说明 760511