A systematic review and meta-analysis of diagnostic outcomes of endoscopic ultrasound guided liver biopsy versus percutaneous liver biopsy

Aims Despite the increasing diffusion of non-invasive tests for the diagnosis of liver diseases, histological assessment through liver biopsy (LB) is still often mandatory especially in unclear cases. Actually, percutaneous approach (PC-LB) is the gold standard. Nowadays, endoscopic ultrasound-guided liver biopsy (EUS-LB) has emerged as an established method to achieve liver tissue sampling. EUS-LB has several advantages such as: sampling of both liver lobes, it allows to obtain liver tissue sampling in case of ascites and toavoid damage to nearby organs and vessels. We performed a syematic review witj meta-analysis (MA) to evaluate the diagnostic outcomes and safety for liver tissue acquisition of PC-LB and EUS-LB in patients with liver diseases and focal liver lesions