癌症
生物
信号转导
癌变
激酶
PI3K/AKT/mTOR通路
癌症研究
蛋白激酶B
癌细胞
MAPK/ERK通路
细胞生物学
遗传学
作者
A Arif,Ameer A. Alameri,Umer Bin Tariq,Shakeel Ahmed Ansari,Hader I. Sakr,Maytham T. Qasim,Fadhil F.M. Aljoborae,Andrés Alexis Ramírez‐Coronel,Hijran Sanaan Jabbar,Gamal A. Gabr,Rasoul Mirzaei,Sajad Karampoor
标识
DOI:10.1016/j.intimp.2022.109581
摘要
Currently, cancer ranks as the second leading cause of death worldwide, and at the same time, the burden of cancer continues to increase. The underlying molecular pathways involved in the initiation and development of cancer are the subject of considerable research worldwide. Further understanding of these pathways may lead to new cancer treatments. Growing data suggest that Tribble's homolog 3 (TRIB3) is essential in oncogenesis in many types of cancer. The mammalian tribbles family's proteins regulate various cellular and physiological functions, such as the cell cycle, stress response, signal transduction, propagation, development, differentiation, immunity, inflammatory processes, and metabolism. To exert their activities, Tribbles proteins must alter key signaling pathways, including the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3 kinase (PI3K)/AKT pathways. Recent evidence supports that TRIB3 dysregulation has been linked to various diseases, including tumor development and chemoresistance. It has been speculated that TRIB3 may either promote or inhibit the onset and development of cancer. However, it is still unclear how TRIB3 performs this dual function in cancer. In this review, we present and discuss the most recent data on the role of TRIB3 in cancer pathophysiology and chemoresistance. Furthermore, we describe in detail the molecular mechanism TRIB3 regulates in cancer.
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