肿瘤微环境
转移
乳腺癌
癌变
癌症研究
免疫系统
癌症
长非编码RNA
细胞外基质
生物
肺癌
医学
免疫学
肿瘤科
核糖核酸
内科学
基因
生物化学
细胞生物学
作者
Yuxi Lei,Zihe Li,Yan Tang
标识
DOI:10.1016/j.critrevonc.2023.104102
摘要
Breast cancer has surpassed lung cancer as the number one cancer worldwide, and invasion and metastasis are still the main causes of death in breast cancer patients. The tumor microenvironment (TME) is an important site for the growth of tumor cells nourished by vascular networks, and various components of the TME interact strongly with cancer cells and are one of the important mechanisms of tumor progression and metastasis. In recent years, many studies have reported that long non-coding RNAs (LncRNAs) are involved in the formation of TME and influence the process of tumorigenesis and metastasis. This paper reviews the basic characteristics and functional roles of LncRNA in breast cancer TME and introduces the various mechanisms of LncRNA in breast cancer microenvironment that induce breast cancer development and metastasis in three directions: immune cells, non-immune cells, and extracellular matrix in TME, providing potential biomarkers or therapeutic targets for clinical practice.
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