丝素
药物输送
药品
黏膜黏附
剂型
胃蛋白酶
胃液
生物制药
体内
靶向给药
化学
自愈水凝胶
控制释放
活性成分
丝绸
药理学
毒品携带者
材料科学
纳米技术
色谱法
生物化学
生物技术
医学
酶
有机化学
生物
复合材料
作者
Natsuda Navamajiti,Apolonia Gardner,Ruonan Cao,Yutaro Sugimoto,Jee Won Yang,Aaron Lopes,Nhi V Phan,Joy Collins,Tiffany Hua,Siriporn Damrongsakkul,Sorada Kanokpanont,Christoph Steiger,Daniel Reker,Robert Langer,Giovanni Traverso
标识
DOI:10.1016/j.xphs.2023.09.001
摘要
Triggerable coatings, such as pH-responsive polymethacrylate copolymers, can be used to protect the active pharmaceutical ingredients contained within oral solid dosage forms from the acidic gastric environment and to facilitate drug delivery directly to the intestine. However, gastrointestinal pH can be highly variable, which can reduce delivery efficiency when using pH-responsive drug delivery technologies. We hypothesized that biomaterials susceptible to proteolysis could be used in combination with other triggerable polymers to develop novel enteric coatings. Bioinformatic analysis suggested that silk fibroin is selectively degradable by enzymes in the small intestine, including chymotrypsin, but resilient to gastric pepsin. Based on the analysis, we developed a silk fibroin-polymethacrylate copolymer coating for oral dosage forms. In vitro and in vivo studies demonstrated that capsules coated with this novel silk fibroin formulation enable pancreatin-dependent drug release. We believe that this novel formulation and extensions thereof have the potential to produce more effective and personalized oral drug delivery systems for vulnerable populations including patients that have impaired and highly variable intestinal physiology.
科研通智能强力驱动
Strongly Powered by AbleSci AI