纳米载体
脂质体
表面电荷
Zeta电位
壳聚糖
透明质酸
阳离子聚合
化学
纳米颗粒
生物物理学
膜
阳离子脂质体
药物输送
控制释放
纳米技术
化学工程
组合化学
材料科学
有机化学
生物化学
遗传增强
物理化学
生物
基因
工程类
遗传学
作者
Jiangjie Wu,Xin Zhang,Hongkuan Yuan,Sailong Wei,X. Wendy Gu,Yingjie Bu,Huiwen He,Yanqin Shi,Meng Ma,Si Chen,Xu Wang
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2023-11-16
卷期号:24 (12): 5687-5697
标识
DOI:10.1021/acs.biomac.3c00679
摘要
The zeta potential of nanoparticles impacts their distribution and metabolism in the body as well as their interaction with medications of varying charges, hence altering therapeutic efficacy and safety. In this paper, the external charges of liposomes were regulated by utilizing a simple and economical method based on competition for protons of cationic chitosan (CS) and anion hyaluronic acid (HA). The charge regulation of a liposomal membrane is generally accomplished by adjusting the ratio of charged lipids within a liposome (e.g., cationic DOTAP or anionic DOPS), the stability of which was maintained by the coating materials of cationic chitosan (CS) or anion hyaluronic acid (HA). A series of nanoparticles could respond to pH-stimulation with adjustable surface charge. Moreover, the sizes of liposomes coated with CS and HA remain within a narrow range. In vitro cytotoxicity tests revealed that the nanocarriers were safe, and the nanoparticles containing antitumor medicines were efficient in tumor therapy. Considering liposomes with different external surface charges could be aimed at diverse therapy purposes. The strategies for regulating liposomal surface charges with high encapsulation rates and certain release cycles reported here could provide a versatile platform as carriers for the delivery of drugs and other macromolecules into human bodies.
科研通智能强力驱动
Strongly Powered by AbleSci AI